Table 2. Parasitologic data, cytokine profile, intestinal egg counts and liver granuloma analysis of C57BL/6 mice vaccinated with rSm29 and challenged with 100 Schistosoma mansoni cercariae.
| Groups a | Cytokine profile in splenocytes (pg/ml) | Male worms Mean±SD | Female worms Mean±SD | Total worms Mean±SD (% protection) | Intestinal eggs Mean±SD (% reduction) | Number of granulomas/liver tissue μm2 10−7 Mean±SD (% reduction) | |
| PBS+CFA/IFA | IL-4 | 7.8±3.0 | 28.2±8.1 | 29.4±6.4 | 57.7±12.2 | 16110.3±5755.2 | 6.74±1.3 |
| IFN-γ | 31.2±5.1 | ||||||
| TNF-α | 15.6±4.2 | ||||||
| IL-10 | 31.3±3.1 | ||||||
| rSm29+CFA/IFA | IL-4 | 7.8±4.6 | 14.6±1.7 | 15.1±4.7 | 29.7±5.3* (51%) | 6440.4±3644.2* (60%) | 3.3±0.6* (50%) |
| IFN-γ | 2538.3±44.6 * | ||||||
| TNF-α | 426.3±231.5* | ||||||
| IL-10 | 425.2±92.2* | ||||||
a
This Table shows one experiment representative of two independent trials with similar results
*: Statistically significant compared to the control group (p<0.05)