Table 3.
Summary of sensitivity analysis for the ARF model
| Biological process | Parameters changed | Effect on period as parameter is increased (decreased) | Effect on amplitude as parameter is increased (decreased) | ||
| × 2 | × 10 | × 2 | × 10 | ||
| p53 turnover | ksynp53, kdegp53 | ↓ (↑) | ↓ (oscillations lost) | ↑ (↓) | ↑ (oscillations lost) |
| Mdm2 turnover | ksynMdm2, kdegMdm2 | ↓ (↑) | oscillations lost (↑) | ↓ (↑) | oscillations lost (↓) |
| Mdm2_mRNA turnover |
ksynMdm2mRNA kdegMdm2mRNA |
↓ (↑) | ↓ (↑) | ↓ (↑) | ↓ (↑) |
| p53/Mdm2 binding and release | kbinMdm2p53, krelMdm2p53 | ↔ (↔) | ↔ (↔) | ↓ (↑) | ↓ (↑) |
| DNA damage | kdam | ↔ (↔) | ↔ (↔) (Greater variability in period for ×10 increase) | ↔ (↔) | ↑ (↓) (Very few cells with oscillations for ×10 decrease) |
| DNA repair | krepair | ↔ (↔) | ↔ (↔) | ↓ (↑) | ↓ (↑) (Very few cells with oscillations for ×10 increase) |
| ARF activation | kactARF | ↔ (↔) | ↔ (↔) | ↑ (↓) | ↑ (↓) (Very few cells with oscillations for ×10 decrease) |
| ARF degradation | kdegARF | ↔ (↔) | ↔ (↔) | ↔ (↔) | ↓ (↑) |
| ARF/Mdm2 binding | kbinARFMdm2 | ↔ (↔) | ↔ (↔) | ↔ (↓) | ↔ (↓) |
| ARF-dependent Mdm2 degradation | kdegARFMdm2 | ↔ (↔) | ↔ (↔) (Period is very irregular in both cases) | ↔ (↓) | ↔ (↓) |
Key
↔ No change, ↓ Decrease in period or amplitude, ↑ Increase in period or amplitude