Table 5.

Comparing ranked lists of hub-likeness properties between the classifier and the hypothetical PINs in MRSA252.

Hub prediction methods	correlation coefficient
Hub classifier	0.320523
Hypothetical PIN – pathway maps	0.108682
Hypothetical PIN – orthologous interactions	0.27396
Hypothetical PIN – interacting domain	-0.291846
Combined hypothetical PIN – (pathway maps + orthologous interactions)	0.23882
Combined hypothetical PIN – (pathway maps + orthologous interactions + interacting domains)	-0.011494

The ranked protein lists based on hub-likeness properties, produced by either the classifier or the hypothetical PINs, has been compared to that of the experimental PIN in MRSA252. The coefficient of Spearman rank order correlation is reported with p-value < 0.05.