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. Author manuscript; available in PMC: 2008 Sep 25.
Published in final edited form as: Org Lett. 2007 Mar 9;9(7):1311–1314. doi: 10.1021/ol070235g

Table 2.

Substrate Scope in the Lewis Acid Catalyzed Friedel-Crafts Cyclizationa

entry substrate yieldb product
1 graphic file with name nihms62009t2.jpg 88% graphic file with name nihms62009t3.jpg
2 graphic file with name nihms62009t4.jpg 93% graphic file with name nihms62009t5.jpg
3 graphic file with name nihms62009t6.jpg 87% graphic file with name nihms62009t7.jpg
4 graphic file with name nihms62009t8.jpg 98% graphic file with name nihms62009t9.jpg
5 graphic file with name nihms62009t10.jpg 97% graphic file with name nihms62009t11.jpg
6 graphic file with name nihms62009t12.jpg 96%c graphic file with name nihms62009t13.jpg
7 graphic file with name nihms62009t14.jpg 93%d graphic file with name nihms62009t15.jpg
8 graphic file with name nihms62009t16.jpg 98% graphic file with name nihms62009t17.jpg
9 graphic file with name nihms62009t18.jpg 80%e graphic file with name nihms62009t19.jpg
10 graphic file with name nihms62009t20.jpg 92% graphic file with name nihms62009t21.jpg
11 graphic file with name nihms62009t22.jpg 89%d graphic file with name nihms62009t23.jpg
12 graphic file with name nihms62009t24.jpg 97% graphic file with name nihms62009t25.jpg
13 graphic file with name nihms62009t26.jpg 97% graphic file with name nihms62009t27.jpg
14 graphic file with name nihms62009t28.jpg 98% graphic file with name nihms62009t29.jpg
15 graphic file with name nihms62009t30.jpg 100% graphic file with name nihms62009t31.jpg
16 graphic file with name nihms62009t32.jpg 87%f graphic file with name nihms62009t33.jpg
17 graphic file with name nihms62009t34.jpg 95%e graphic file with name nihms62009t35.jpg
a

InCl3 (10 mol %), 4 Å MS, CH2Cl2 (0.05 M) 16 h, rt.

b

Yield of isolated product.

c

30 mol % catalyst, 16 h.

d

20 mol % catalyst, 48 h.

e

20 mol % catalyst, 72 h.

f

20 mol % catalyst, 16 h.