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Resistance to high-fat diet-induced obesity. A, FABP4-ghrelin transgenic mice were resistant to body weight gain when fed with high-fat diets. ANOVA demonstrated a significant decrement of body weight in FABP4-ghrelin transgenic mice compared with wild-type mice (*, P < 0.05). B, DEXA measurement showed a significant decrease of fat mass in FABP4-ghrelin transgenic mice relative to the control wild-type mice (*, P < 0.05), whereas lean mass was unchanged.
