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. 2008 May 29;149(9):4615–4621. doi: 10.1210/en.2008-0511

Figure 2.

Figure 2

Selective activation of ERβ attenuates the induction of PR expression by ERα in the VMN, but not the MPN. The mean (sem) total amount of PR-ir within the VMNvl or the MPN of female rats on P7 treated with vehicle (n = 11), EB (20 μg/kg, n = 8), or the ERα selective agonist, PPT (2 mg/kg, n = 8) or PPT in combination with the ERβ selective agonist, DPN, at 0.5, 3.5, or 5 mg/kg (n = 10, 9, 7) on P5 and P6. A, VMNvl. PR-ir levels were significantly higher after PPT treatment (2 mg/kg) compared with EB treatment. The effect of PPT was significantly attenuated by the addition of DPN at all doses. PR-ir was significantly higher in all treatment groups compared with vehicle. B, MPN. PPT treatment alone, or PPT in combination with any dose of DPN, did not significantly alter PR-ir levels compared with EB treatment. PR-ir was significantly higher in all treatment groups compared with vehicle. *, Significantly different from vehicle (P < 0.001); +, significantly different from EB (P < 0.01); #, significantly different from PPT (3.5 mg/kg DPN P < 0.001; 0.5 and 5 mg/kg DPN, P < 0.05).