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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Jul;32(7):1309–1320. doi: 10.1111/j.1530-0277.2008.00699.x

Fig. 1.

Fig. 1

Splenic dendritic cell (DC) numbers are decreased in ethanol (EtOH) fed mice, beginning at 4 weeks of treatment. (A) Gating strategy for splenic plasmacytoid DC (pDC; CD11cloB220+) and conventional DC (cDC; CD11c+B220-). Both populations are major histocompatability complex class II+ (data not shown). Total DC were determined as the combination of these 2 gates. (B) Decreased number of splenic DC in C57Bl/6 EtOH-fed mice, n = 4 to 11 mice/group. (C) Decreased number of splenic total DC, cDC, and pDC in C57Bl/6 EtOH-fed mice, normalized to the number found in age-matched controls (represented as 1). (D) Decreased number of total splenic DC in C3H and BALB/c EtOH-fed mice after 13 weeks of feeding. DC numbers in EtOH-fed mice normalized to water controls: C3H = 0.28, BALB/c = 0.57, n = 4 to 6 mice/group. (E) Decreased total splenocyte recovery from C57Bl/6 EtOH mice, n = 7 to 11 mice/group. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 for water vs. EtOH. Error bars = SEM.