Table 5.

IgG subclass levels separated by FcγRIIa R131H genotypes and alleles in the Fulani and Dogon ethnic groups

	Dogon						Fulani
	no.	age	IgG1	IgG2	IgG3	IgG4	no.	age	IgG1	IgG2	IgG3	IgG4
H/H	24	15	15 ± 2.9	0.4 ± 5.6	4.5 ± 3.5	0.54 ± 2.0	39	15	34 ± 4.4	5.9 ± 11	6.3 ± 2.5	0.29 ± 7.8
H/R	69	16	17 ± 3.9	1.2 ± 6.7	3.8 ± 2.6	2.3 ± 2.3	68	23	38 ± 3.7	7.5 ± 9.1	12 ± 2.8	1.8 ± 2.6
R/R	64	20	24 ± 3.5	1.5 ± 8.1	6.2 ± 2.9	0.41 ± 2.9	36	21	24 ± 3.4	2.4 ± 9.8	9.5 ± 2.9	0.42 ± 2.3
p-valuea		0.07	0.2	0.02	0.03	0.5		0.07	0.2	0.05	0.01	0.04
R-allele carriers	133	18	20 ± 3.7	1.3 ± 7.3	4.8 ± 2.8	0.43 ± 2.5	93	22	33 ± 3.6	5.0 ± 10	11 ± 2.8	0.5 ± 2.5
p-valueb		0.3	0.4	0.007	0.8	0.2		0.03	0.08	0.1	0.009	0.4
H-allele carriers	104	22	17 ± 3.6	0.89 ± 6.7	3.9 ± 2.8	0.46 ± 2.3	107	20	37 ± 3.9	6.8 ± 9.5	9.4 ± 2.8	0.44 ± 4.4
p-valuec		0.02	0.9	0.7	0.004	0.02		0.9	0.09	0.02	0.9	0.8

The results are expressed in ELISA units and presented as geometric means ± SD.

^a Statistical analysis of differences in IgG subclass levels between the different genotypes tested with ANOVA

^b Statistical analysis of differences in IgG subclass levels between the R-allele carriers and HH homozygotes Mann-Whitney.

^c Statistical analysis of differences in IgG subclass levels between the H-allele carriers and RR homozygotes by Mann-Whitney.