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. Author manuscript; available in PMC: 2008 Sep 26.
Published in final edited form as: Pain. 2008 Mar 19;138(2):423–439. doi: 10.1016/j.pain.2008.01.023

Table 1.

ED50 values of the analgesic effect of prototype opioid agonists in KOPr WT and KO mice

ED50 KOPr WT KOPr KO
Fentanyl 36.3 (26.3−50.1) μg/kg 28.1 (22.3−35.4) μg/kg
SNC80 25.1 (11.0−57.3) mg/kg 18.0 (8.0−40.3) mg/kg
U69593 0.68 (0.05−9.8) mg/kg 34.2 (24.2−48.6)a mg/kg

The analgesic effects of the MOPr agonist fentanyl and the DOPr agonist SNC80 did not differ between WT and KO mice.

a

U69593-evoked analgesia was decreased 50.5-fold in KO mice (P < 0.004).