Figure 2.
Conservation of human poly(A) sites in mouse, rat and chicken. (A) Percent of human poly(A) sites of different types that are conserved in mouse and rat. P-values (Chi-squared test) for difference in conservation between F and L types are 3.52 × 10−67 for human versus mouse, and 3.72 × 10−56 for human versus rat. Error bars are standard deviation. (B) Conservation of poly(A) site type between human and mouse orthologous poly(A) sites (P < 2.2 × 10−16, Chi-squared test). (C) Percent of human and mouse poly(A) sites conserved in chicken. P-values (Chi-squared test) for difference in conservation between F and L types are 1.34 × 10−16 for human versus chicken and 4.39 × 10−7 for mouse versus chicken. (D) Percent of genes with alternative poly(A) sites for genes with orthologs in chicken (named ‘old’, 8140 in total) and genes without orthologs in chicken (named ‘new’, 4284 in total). P-value (Chi-squared test) for the difference is 8.39 × 10−145.