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. 2008 Aug 21;36(17):5482–5515. doi: 10.1093/nar/gkn517

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Whole-spectra melting data and the test of the two-state assumption. Thermal denaturation of the human telomere quadruplex sequence 5′AGGG(TTAGGG)₃ in a solution containing 0.185 M NaCl is shown as monitored by UV absorbance (A) or CD (B). The corresponding two-wavelength parametric plots to test the two-state assumption (144) are shown in (C and D). The nonlearity of the the data in panels C and D indicate that the denaturation of the quadruplex is not a simple two-state process, and the intermediate states must be included in the reaction mechanism.