Table 2.

Energetics of human telomere quadruplex unfolding

Sequence	Cation	Tm°C	ΔH kcal mol−1	ΔS cal mol-K−1	ΔG(310K) kcal mol−1	Reference
1. 5′-(TTAGGG)4	70 mM Na+	49	38.0	119	1.4	(154)
	70 mM K+	63	49.0	147	3.8
2. 5′-AGGG(TTAGGG)3	100 mM Na+	56	54.0	163	3.1	(138)
	100 mM K+	63	57.0	169	4.4
5′-TTAAGGG(TTAGGG)3	100 mM Na+	44	38.5	121	0.9
	100 mM K+	55	63	193	3.5
3. 5′-GGG(TTAGGG)3	100 mM Na+	63.7	72.7	192	5.8	(155)
	100 mM K+	69.3	77.5	202	7.3
4. 5′-AGGG(TTAGGG)3a	100 mM Na+	42.8	51.4	153	0.9	(156)
	100 mM K+	61.8	66.2	186.5	4.9

ΔH, ΔS and ΔG are for the unfolding direction.

^aFluorescently labeled on 5′ and 3′ ends.