Table 4.

Observed thermodynamics of unfolding G-quadruplexes at 110 mM K⁺

Species	Tm/K	ΔH/ kcal mol−1	ΔG(293)/ kcal mol−1	ΔG(310)/ kcal mol−1
NHEIIIa	357	41	7.6	5.4
22GGa	339	34–45b	4.7	2.9–3.8
G3TTAc	355	66	11.5	8.4
G3ATc	321	27.5	2.4	0.94 (3.2)
G3T2c	345	40	6	4.1 (6.9)
Myc-1c	357.5	45	8.1	6.0 (9)

^aData from Olsen et al. (134) for 0.075 M. NHEIII: d(TG₄AG₃TG₄AG₃TG₄A₂G₂); 22GG, d(AG₃T₂AG₃T₂AG₃T₂AG₃); G3TTA, Q-d(TG₃T₂AG₃T₂AG₃T₂AG₃)-F (Q, F quencher and fluorophore, respectively); G3AT; F-d(G₃A₃G₃T₃G₃T₃G₃)-Q; G3T2, F-d(G₃T₂G₃T₂G₃T₂G₃)-Q; Myc-1, F-d(G₄AG₄TG₄AG₄)-Q.

^bvan't Hoff and calorimetric enthalpies—transition not pure two state.

^cData from ref. (75) at 100 mM K⁺ (G3TTA) and 5 mM (G3AT, G3T2, Myc1). Values in parentheses calculated for 0.1 M K⁺ using the strongest salt dependence of T_m from ref. (134). No correction for heat capacity differences has been made.