Table 1.

Stabilization temperature (ΔT_m) of G-quadruplex DNA, i-motif DNA, dsDNA (G-quadruplex/i-motif complementary duplex DNA) and CT-DNA by ligand (L, 3 µM), M-enantiomer (M, 1 µM) and P-enantiomer (P, 1 µM) of [Ni₂L₃]⁴⁺ and [Fe₂L₃]⁴⁺, respectively, in 10 mM Tris buffer containing 100 mM NaCl at pH 7.2 or pH 5.5 (for i-motif DNA melting studies)

Compound	ΔTm (°C)
	G-quadruplex	i-motif	dsDNA	CT-DNA
L	0	−0.5	0	0
[Ni2L3]4+-M	0	−2.5	0	0.7
[Ni2L3]4+-P	10.6	−2.8	0	0.5
[Fe2L3]4+-M	0	−2.2	0	1.3
[Fe2L3]4+-P	10.8	−2.8	0	1.0

The DNA concentration was 1 µM/strand or in equivalent concentration for dsDNA.