Table 1. Baseline Characteristics of the Substudy Sample According to Treatment Group.
| Variable | Trandolapril | Placebo |
|---|---|---|
| N | 152 | 148 |
| Age, y | 64.2±7.9* | 62.9±7.7 |
| Women (% of patients) | 16 (11) | 13 (9) |
| Height, cm | 173±9 | 173±8 |
| Weight, kg | 86±16* | 83±14 |
| Body mass index, kg/m2 | 29±4* | 28±4 |
| Systolic pressure, mm Hg | 133±16 | 133±17 |
| Diastolic pressure, mm Hg | 78±9 | 80±10 |
| Mean pressure, mm Hg | 97±10 | 97±11 |
| Heart rate, min−1 | 59±10 | 61±11 |
| Serum creatinine, mg/dL | 1.05±0.23 | 1.04±0.21 |
| LV ejection fraction, % | 57.1±8.1* | 58.7±8.4 |
| Medical history, N (%) | ||
| Diabetes | 16 (11) | 10 (7) |
| Documented MI | 104 (68) | 93 (63) |
| Angina pectoris | 86 (57) | 91 (62) |
| PTCA or CABG | 111 (73) | 117 (79) |
| Hypertension | 54 (36) | 50 (34) |
| Stroke | 8 (5) | 4 (3) |
| Current smoker | 22 (15) | 23 (16) |
| Medications, N (%) | ||
| Calcium channel blocker | 44 (29) | 44 (30) |
| β blocker | 99 (65)* | 82 (55) |
| Aspirin/antiplatelet | 133 (88)* | 138 (93) |
| Lipid-lowering drug | 114 (75) | 106 (72) |
The following medications were being taken by <10% of patients with no differences between groups: antiarrhythmic, anticoagulant, digitalis, diuretics, and insulin. LV indicates left ventricular; MI, myocardial infarction; PTCA, percutaneous coronary angioplasty; CABG, aortocoronary bypass graft surgery.
*
P<0.15 for trandolapril vs placebo.