Table 2. On-Treatment Pulsatile Hemodynamic Variables According to Treatment Group.
| Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
| Variable | Trandolapril, Mean
(95% CI) |
Placebo, Mean
(95% CI) |
P | Trandolapril, Mean
(95% CI) |
Placebo, Mean
(95% CI) |
P |
| Mean pressure, mm Hg | 93 (91 to 95) | 96 (95 to 98) | <0.001 | 93 (91 to 95) | 97 (94 to 99) | 0.004 |
| Brachial pulse pressure, mm Hg | 63 (61 to 66) | 65 (62 to 68) | 0.40 | 61 (57 to 64) | 63 (60 to 67) | 0.15 |
| Carotid pulse pressure, mm Hg | 64 (61 to 67) | 65 (62 to 68) | 0.77 | 61 (57 to 64) | 62 (58 to 66) | 0.41 |
| Carotid to femoral PWV, m/s | 10.4 (10.0 to 10.9) | 11.3 (10.7 to 11.8) | 0.02 | 10.5 (10.0 to 11.1) | 11.9 (11.2 to 12.6) | <0.001 |
| Aortic compliance, 10−5 cm4/dyne | 0.49 (0.45 to 0.54) | 0.46 (0.41 to 0.51) | 0.38 | 0.50 (0.45 to 0.57) | 0.44 (0.38 to 0.49) | 0.02 |
| Augmentation index, % | 14.7 (12.7 to 16.7) | 15.8 (13.6 to 18.0) | 0.46 | 11.9 (9.1 to 14.7) | 12.7 (9.7 to 15.6) | 0.61 |
| Characteristic impedance, dyne×s/cm5 | 199 (188 to 211) | 199 (186 to 213) | 0.96 | 191 (176 to 207) | 197 (181 to 215) | 0.46 |
| Total arterial compliance, mL/mm Hg | 1.66 (1.57 to 1.75) | 1.66 (1.55 to 1.77) | 0.98 | 1.65 (1.51 to 1.79) | 1.64 (1.50 to 1.79) | 0.95 |
Adjusted models include: age, body mass index, ejection fraction, and β-blocker and aspirin usage. Values for aortic compliance, carotid–femoral PWV, characteristic impedance, and total arterial compliance represent geometric means.