Figure 7.
Blockade of inhibition in the WT retina causes a long-latency ON response to emerge. Treatment of WT retinas with antagonists to GABAA (SR95531), GABAB (CGP55845), GABAC (TPMPA), and glycine (strychnine) receptors leads to generation of a long-latency ON response in many RGCs. A–C, The top panels show examples of neuronal responses (as trial spike rasters and their corresponding PSTHs) to 3 s light stimulus presentations in control saline, whereas the bottom panels show the responses of the same neurons while the retina was perfused with the antagonist mixture. Short-latency ON responses were maintained, and a long-latency ON response appeared. In C, the neuron also gained an OFF component to its response in the antagonists. Light/dark bars show the timing of the light stimulus. Frequency (Freq) is in impulses (spikes) per second (imp/sec).