Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of compound 1
Reagents and Conditions: (a) i. 10% Pd-C, H2, MeOH; ii. 2N LiOH, 1,4-dioxane, then 1N HCl, 96% over two steps; (b) i. aminodiphenylmethane, EDC, HOBt, N,N-diisopropylethylamine, CH2Cl2, overnight; ii. 4N HCl in 1,4-dioxane, MeOH; iii. Boc-N-methyl-L-alanine, EDC, HOBt, N,N-diisopropylethylamine, CH2Cl2; iv. 4N HCl in 1,4-dioxane, MeOH, 72% over four steps.
