Table 1.
In vivo tumorigenicity of ovarian tumor sphere-forming cells
| Sample/cell type | Cell dose* | Injection site | Tumor formation† | Latency (d)‡ | Serial transplantation rate |
|---|---|---|---|---|---|
| T1 | |||||
| Sphere-forming | 100 | S.c. | 2/2 | 86, 102 | 5/5 |
| 1,000 | S.c. | 2/2 | 74, 81 | — | |
| 10,000 | S.c. | 2/2 | 60, 77 | — | |
| Bulk tumor | 10,000 | S.c. | 0/2 | — | — |
| 100,000 | S.c. | 0/2 | — | — | |
| 1,000,000 | S.c. | 0/2 | — | — | |
| Differentiated | 10,000 | S.c. | 0/2 | — | — |
| 100,000 | S.c. | 0/2 | — | — | |
| 1,000,000 | S.c. | 1/2 | 84 | — | |
| T2 | |||||
| Sphere-forming | 100 | S.c. | 2/2 | 73, 96 | 5/5 |
| 1,000 | S.c. | 2/2 | 65, 75 | — | |
| 10,000 | S.c. | 2/2 | 62, 69 | — | |
| 5,000 | I.p. | 1/1 | 75 | 3/3 | |
| Bulk tumor | 10,000 | S.c. | 0/2 | — | — |
| 100,000 | S.c. | 0/2 | — | — | |
| 1,000,000 | S.c. | 0/2 | — | — | |
| 50,000 | I.p. | 0/1 | — | — | |
| 500,000 | I.p. | 0/1 | — | — | |
| Differentiated | 10,000 | S.c. | 0/2 | — | — |
| 100,000 | S.c. | 0/2 | — | — | |
| 1,000,000 | S.c. | 1/2 | 92 | — | |
| 50,000 | I.p. | 0/1 | — | — | |
| 500,000 | I.p. | 0/1 | — | — |
*
Number of cells per injection.
†
Number of tumors formed per number of injection.
‡
The time from injection to the first appearance of a palpable tumor.