Table 3.

Significant synergistic transcriptional factors in down-regulated genes from Day 1 to Day 2

Motif	Occurrence Number	p-value	q-value	Transcription Factors
RACCACGTGCTC_GGGRATTTCC	17	0.00105	0.0122	CMYC NFKAPPAB65
HWAAATCAATAW_TRRCCAATSRN	4	0.0028	0.0122	HNF6 NFY
GCCNNNRGS_ACWTCCK	3	0.00304	0.0122	AP2ALPHA PEA3
AGWACATNWTGTTCT_SGGRNTTTCC	3	0.00523	0.0157	AR CREL
AGACNBCNN_ASMCTTGGGSRGGG	2	0.00859	0.0189	SMAD SP3

Significant synergistic transcriptional factors in down-regulated genes from Day 1 to Day 2. The Motif column shows the consensus binding site sequence for the transcriptional factor where two motifs are separated by an underscore. The second column lists the total occurrence number of genes containing that motif in the promoter regions. The p-value column illustrates the Mann-Whitney rank sum p-value. The q-value column shows the multiple testing corrected FDR q-value. The last column lists the name of the transcription factors. The total number of down-regulated Refseq genes with raw expression levels at least 100 in Day 1 is 3728.