Figure 1.

Amino acid sequence of MDR1-Pgp from residue K702 through E782. Residues predicted to constitute potential TM segments 7a, 7b, and 8 are outlined. Pertinent residues and fusion sites for specific plasmids are included, although N-terminal and some C-terminal flanking sequences are left out for clarity. P represents the C-terminal translocation reporter derived from bovine prolactin. Dashed areas represent deleted amino acid residues. Mutated residues are boxed; inserted residues are underlined. Outlined residues represent putative TM domains, and bold residues represent intervening sequences. Residues NFKLLSHCLLVT (plasmids S.gG.X.P) are contributed by the gG reporter domain.