Abstract
Earlier studies with antirabies serum and vaccine have been extended to determine the value of serum, vaccine, or serum and vaccine combined against rabies challenges of increasing degrees of severity. While serum alone was not found to have any protective effect, vaccine alone was sufficient against mild challenges, the superiority of combined therapy with both serum and vaccine becoming evident at a challenge of about 50 LD50. With challenges of over 300 LD50 no treatment was of any value. It was also found that with a recommended optimum dose of serum, the usual vaccine dose could be halved—a matter of importance in countries with a high incidence of neuroparalytic accidents following administration of nervous tissue vaccine.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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