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a) The β4-β5 hairpin is shown in the bound (in red, cAMP-bound wild type and R307E) and apo (R348 in grey and R307W in green) states. b) and c) Van der Waals interactions of the purine base of cAMP (b) or cGMP (c) with Arg 348 and residues in the β4-β5 hairpin.
