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. Author manuscript; available in PMC: 2009 Sep 5.
Published in final edited form as: J Mol Biol. 2008 Jun 10;381(3):655–669. doi: 10.1016/j.jmb.2008.06.011

Figure 3. Ligand interactions.

Figure 3

a) Comparison of binding pocket interactions from the cGMP-bound (left) and cAMP-bound (right) structures. b) Dose response relations for S308V (left) and S308A (right) activation by cAMP and cGMP. Solid lines are fits to the Hill equation. For 308V: cAMP (■): K½ = 0.1 ± 0.03 μM, Hill coefficient (n) of 1.1 ± 0.4; cGMP (●): K½ = 1.6 ± 0.2 μM, n = 1.3 ± 0.2. For S308A: cAMP (■): K½ = 0.3 ± 0.1 μM, Hill coefficient (n) of 0.9 ± 0.2; cGMP (●): K½ = 4.1 ± 0.6 μM, n = 1.1 ± 0.1.