TABLE 1.

Inhibition of the enzymatic activity of MetAP in purified form and in cellular environment by metalloform-selective MetAP inhibitors 1–6

^a Metal concentrations used to activate the enzyme: Co(II), 100 μm; Mn(II), 100 μm; and Fe(II), 6 μm.

^b Values reported in Ref. 29.

^c Values reported in Ref. 24.