TABLE 2.
Inhibition of growth of some Gram-positive and Gram-negative bacterial strains by metalloform-selective MetAP inhibitors 1–6
|
Bacterial strain
|
Inhibition of bacterial cell growth (IC50,
μm)a,b
|
|
|---|---|---|
| 5 | 6 | |
| E. coli AS19 | 117 (91) | 15 (7) |
| E. coli D22 | 6 (4) | 9 (3) |
| E. coli RL25 | 107 (54) | 90 (41) |
| E. coli RL436 | 113 (33) | 52 (15) |
| E. coli ATCC 25922 | 110 (65) | 58 (30) |
| B. subtilis | 67 (41) | 22 (8) |
| B. megaterium | 70 (73) | 15 (13) |
a
Inhibitors 1-4 showed no inhibition for all seven strains tested at the highest concentration of 1 mm.
b
Values in parentheses are MIC in mg/liter.