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SUV3 knockdown alters mitochondrial physiology. A, measurement of superoxide formation by mitoSOX Red staining upon SUV3 knockdown in control (Ctrl) and SUV3-ablated LK6 cells (SUV3 induced for 2, 4, 6, 8 days). B, detection of mitochondria membrane potential by JC-1 staining in the induced LK6 cells (2, 4, or 6 days with doxycycline (dox)). C, histogram to show the ATP levels measured in parental, LK6, SUV3-depleted LK6, and 143B-ρ0 cells.
