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Stimulation of NEIL1 DNA glycosylase activity by FEN-1. A, effect of FEN-1 (2–20 nm) on NEIL1 (10 nm) with duplex, bubble, fork and single-stranded DNA substrates containing 5-OHU (Table 1). S and P, the 5′ 32P-labeled uncleaved substrate (51 nt) and NEIL1 incision product (25 nt), respectively. Lane 6, FEN-1 alone as control for possible substrate cleavage by FEN-1. B, dose-dependent stimulation of NEIL1 activity for various substrates by FEN-1.
