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Physical association of NEIL1 and FEN-1 is required for stimulation of NEIL1 activity. A, activities of 2 and 20 nm each of WT NEIL1 and 1–311 mutant with fork substrate. B, effect of FEN-1 on DNA glycosylase activity of NEIL1 C-terminal deletion peptide (residues 1–311). C, effect of noninteracting point mutants of FEN-1 on NEIL1 activity with fork oligonucleotide. The E340A and D347A point mutants of NEIL1 were stimulated to a lesser extent by FEN-1 in comparison with WT NEIL1.
