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. 2008 Sep;7(9):1737–1747. doi: 10.1074/mcp.M800109-MCP200

Fig. 5.

Fig. 5.

Alteration of HMG-CoA synthase. A, the differential expression pattern of HMG-CoA synthase on 2-D gels in SAMR1-1m (a), SAMP8-1m (b), SAMR1-6m (c), and SAMP8-6m (d).The protein is indicated by arrows on each gel. B, the MS spectra of two peptides from HMG-CoA synthase in the orthogonal experiments. a1 and a2 represent peptides from SAMR1-1m and SAMP8-1m labeled with the light chain and the heavy chain, respectively (forward labeling of the 1-month group); b1 and b2 represent peptides from the reverse labeling of the 1-month group; c1 and c2 represent peptides from SAMR1-6m and SAMP8-6m labeled with the light chain and the heavy chain (forward labeling of the 6-month group), respectively; and d1 and d2 represent peptides from the reverse labeling of the 6-month group. C, alteration at the transcription levels of HMG-CoA synthase. Error bars indicate S.E. from three independent experiments; *, p < 0.05. D, activity of HMG-CoA synthase in liver homogenates. Error bars indicate S.E. from five independent experiments; *, p < 0.05. Intens., intensity.