Table IV.
Phenotypic comparison of SAMR1 and SAMP8
The mice used were 1 month and 6 months of age, respectively. Each value represents the mean ± S.E.
| Parameter | 1 month
|
6 months
|
||
|---|---|---|---|---|
| SAMR1-1m | SAMP8-1m | SAMR1-6m | SAMP8-6m | |
| Number of mice | 5 | 5 | 5 | 5 |
| Body weight (g) | 23.1 ± 1.3 | 21.2 ± 1.5 | 31.3 ± 1.5 | 29.1 ± 2.1 |
| Liver weight (g) | 1.40 ± 0.13 | 1.23 ± 0.13 | 1.71 ± 0.10 | 1.75 ± 0.17 |
| Liver weight/body weight (%) | 6.1 ± 0.5 | 5.8 ± 0.6 | 5.5 ± 0.5 | 6.0 ± 0.3 |
| Liver triglycerides (mg/g protein) | 12.2 ± 4.9 | 14.6 ± 3.5 | 10.5 ± 3.6 | 21.7 ± 5.4a |
| Liver acetyl-CoA (nmol/mg protein) | 6.0 ± 0.8 | 5.9 ± 1.1 | 5.6 ± 0.6 | 4.1 ± 0.8b |
| Liver ATP (nmol/mg protein) | 30.3 ± 4.1 | 27.7 ± 3.5 | 37.0 ± 3.8 | 23.4 ± 4.6a |
a
p < 0.01 (Student’s t test).
b
p < 0.05 (Student’s t test).