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Distribution analysis of changes in the cellular Tyr(P)-containing proteome of PTP1B wild-type and KO cells under normal conditions. Tyr(P) peptides were binned according to the log2 values of their PTP1B KO/wild-type ratios. Values for the mean and S.D. were obtained by Gaussian regression analysis. Note the normal distribution of the whole population of Tyr(P) peptides and the outliers that were up-regulated in PTP1B-deficient cells. pTyr, phosphotyrosine; wt, wild type.
