Fig. 2.

TDM-elicited proinflammatory mediator production from lungs of deficient and wild-type mice. Levels of pulmonary proinflammatory mediators IL-1β, IL-6 and TNF-α were quantified post-challenge in the lungs of mice administered TDM. Mean values per lung are shown for mice deficient in TNF-α, C5a or IL-6 prior to challenge (day 0) and at 4, 7 and 14 days post-TDM challenge. Comparisons are made to the wild-type control animals administered TDM. Data are represented as the mean ± SD for duplicate wells per mouse (n = 4–6 mice per group per time point). *P < 0.05; nd, none detected.