. Author manuscript; available in PMC: 2009 Jun 24.

Published in final edited form as: J Control Release. 2008 Mar 21;128(3):224–232. doi: 10.1016/j.jconrel.2008.03.013

Table 3.

Pharmacokinetic parameters of LMWH-loaded PLGA microspheric formulations. Data represent mean ± SEM (n=5-6)

Formulations	Pharmacokinetic parameters

	C_max (U/ml)	T_max (h)	AUC_0-24 (U.h/ml)	AUMC_0-24	T_1/2 (h)	MRT (h)	F_relative (%)
Plain LMWH Subcutaneous	0.33±0.03	4.4±0.31	3.98±0.22	36.6±1.72	4.35±0.33	7.79±0.60	----
Plain LMWH pulmonary	0.20±0.01	2.2±0.44	1.58±0.12	9.63±0.77	4.28±0.31	6.63±0.47	39.7±3.0
PM-2	0.07±0.04	0.8±0.4	1.05±0.11	10.57±2.04	12.13±0.93	18.43±1.42	26.38±2.8
PM-SP-2	0.13±0.03	1.7±0.3	1.98±0.29	21.22±1.86	23.75±2.97	34.33±4.29	49.74±7.31
PM-SA-2	0.20±0.04	6.9±0.89	3.64±0.36	43.14±3.7	25.28±2.81	39.09±4.34	91.45±9.01
PM-PEI-2	0.21±0.03	7.6±0.70	3.37±0.40	40.8±2.38	20.13±1.68	32.39±2.70	84.67±10.11

SEM: Standard error of the mean