Table 6.
Cardiovascular Risk Assessment and Need for Lipid-Lowering Therapy (LLT) in the VACH Cohort Population Accord-ing to Current Usage of Antiretroviral Therapy (ART) Drug Classes
| NRTI Only | Combination with | Combination with | Combination with | Total | p | |
| (n = 233) | NNRTI (n = 1094) | PI (n = 990) | PI plus NNRTI (n = 41) | (n = 2358) | ||
| Risk factor number, n (%) [95%CI] | 0.0001 | |||||
| 0 | 42 (18.0%) | 326 (29.8%) | 228 (23.0%) | 17 (41.5%) | 613 (26.0%) | |
| [13.3%,23.6%] | [27.1%,32.6%] | [20.4%,25.8%] | [26.3%,57.9%] | [24.2%,27.8%] | ||
| 1 | 78 (33.5%) | 363 (33.2%) | 345 (34.8%) | 13 (31.7%) | 799 (33.9%) | |
| [27.4%,39.9%] | [30.4%,36.1%] | [31.9%,37.9%] | [18.1%,48.1%] | [32.0%,35.8%] | ||
| ≥ 2 | 113 (48.5%) | 405 (37.0%) | 417 (42.1%) | 11 (26.8%) | 946 (40.1%) | |
| [41.9%,55.1%] | [34.2%,40.0%] | [39.0%,45.3%] | [14.2%,42.9%] | [38.1%,42.1%] | ||
| 10-yr Cardiovascular risk estimate, n (%) [95%CI] | ||||||
| Low | 107 (45.9%) | 548 (50.1%) | 475 (48.0%) | 27 (65.9%) | 1157 (49.1%) | 0.0184 |
| [39.4%,52.6%] | [47.1%,53.1%] | [44.8%,51.1%] | [49.4%,79.9%] | [47.0%,51.1%] | ||
| Moderate | 65 (27.9%) | 280 (25.6%) | 289 (29.2%) | 6 (14.6%) | 640 (27.1%) | |
| [22.2%,34.1%] | [23.0%,28.3%] | [26.4%,32.1%] | [5.6%,29.2%] | [25.4%,29.0%] | ||
| Moderate-high | 34 (14.6%) | 124 (11.3%) | 138 (13.9%) | 4 (9.8%) | 300 (12.7%) | |
| [10.3%,19.8%] | [9.5%,13.4%] | [11.8%,16.3%] | [2.7%,23.1%] | [11.4%,14.1%] | ||
| High | 27 (11.6%) | 142 (13.0%) | 88 (8.9%) | 4 (9.8%) | 261 (11.1%) | |
| [7.8%,16.4%] | [11.0%,15.1%] | [7.2%,10.8%] | [2.7%,23.1%] | [9.8%,12.4%] | ||
| Lipid-lowering therapy, n (%) [95%CI] & | ||||||
| Needed | 26 (11.3%) | 201 (18.5%) | 177 (17.9%) | 11 (26.8%) | 415 (17.7%) | 0.0243 |
| [7.5%,16.1%] | [16.2%,20.9%] | [15.6%,20.5%] | [14.2%,42.9%] | [16.2%,19.3%] | ||
| Current use | 6 (2.6%) | 36 (3.3%) | 21 (2.1%) | 0 (0.0%) | 63 (2.7%) | 0.2725 |
| [1.0%,5.5%] | [2.3%,4.5%] | [1.3%,3.2%] | [0.0%,7.0%] | [2.1%,3.4%] | ||
| Type of therapy, n (%) [95%CI] | 0.3161 | |||||
| None | 227 (97.4%) | 1058 (96.7%) | 969 (97.9%) | 41 (100.0%) | 2295 (97.3%) | |
| [94.5%,99.0%] | [95.5%,97.7%] | [96.8%,98.7%] | [93.0%,100.0%] | [96.6%,97.9%] | ||
| Fibrates | 3 (1.3%) | 12 (1.1%) | 12 (1.2%) | 0 (0.0%) | 27 (1.1%) | |
| [0.3%,3.7%] | [0.6%,1.9%] | [0.6%,2.1%] | [0.0%,7.0%] | [0.8%,1.7%] | ||
| Statines | 3 (1.3%) | 24 (2.2%) | 9 (0.9%) | 0 (0.0%) | 36 (1.5%) | |
| [0.3%,3.7%] | [1.4%,3.2%] | [0.4%,1.7%] | [0.0%,7.0%] | [1.1%,2.1%] | ||
Descriptive statistics are n (%) [95%CI] for qualitative, and median [IQR] for qualitative variables.&Percentage of missingness <1%; null percentage for the rest of variables.