Table 4.
Three distinct patterns of target specificity
| Pubchem ID (SID) | aEC50 [μM] (MV-Alaska) | aEC50 [μM] (CDV-752) | aEC50 [μM] (HPIV3) |
|---|---|---|---|
| MV specific | |||
| 14722514 | 0.7 ± 0.1 | no activity detected | no activity detected |
| 22408576 | 2.3 ± 0.4 | no activity detected | no activity detected |
| 4261934 | 2.4 ± 0.5 | no activity detected | no activity detected |
| 14743644 | 2.7 ± 0.5 | no activity detected | no activity detected |
| 846635 | 2.7 ± 0.2 | no activity detected | no activity detected |
| 14735307 | b3.3 ± 0.9 | no activity detected | no activity detected |
| 852230 | 3.3 ± 0.1 | no activity detected | no activity detected |
| 4259333 | 3.3 ± 0.4 | no activity detected | no activity detected |
| 17433375 | 3.7 ± 0.2 | no activity detected | no activity detected |
| 17505573 | 3.8 ± 0.5 | no activity detected | no activity detected |
| 22410899 | 3.9 ± 0.1 | no activity detected | no activity detected |
| MV and CDV (genus morbillivirus) specific | |||
| 17416393 | 1.5 ± 0.3 | 12.9 ± 0.7 | no activity detected |
| 22402685 | 1.9 ± 0.2 | 2.1 ± 0.3 | no activity detected |
| 4265637 | 3.0 ± 0.2 | 6.7 ± 0.1 | no activity detected |
| 22415156 | 3.6 ± 0.1 | 11.0 ± 0.1 | no activity detected |
| 14723513 | 3.7 ± 0.1 | 26.8 ± 8.7 | no activity detected |
| 22415419 | 4.5 ± 0.9 | 5.0 ± 0.2 | no activity detected |
| 4245209 | 5.9 ± 1.7 | 31.1 | no activity detected |
| 22415706 | 6.7 ± 0.3 | 12.9 | no activity detected |
| active against different paramyxovirus genera | |||
| 22407448 | b0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| 7973070 | 0.4 ± 0.1 | 1.0 ± 0.1 | 1.9 ± 0.1 |
| 17409378 | 0.7 ± 0.1 | no activity detected | 1.7 ± 0.2 |
| 22404943 | 0.7 ± 0.1 | 0.4 ± 0.1 | 0.6 ± 0.1 |
| 4242806 | 1.4 ± 0.2 | 2.1 ± 0.1 | 2.0 ± 0.1 |
| 22407466 | 2.1 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1 |
| 4256670 | 2.2 ± 0.3 | 3.9 ± 0.2 | 5.8 ± 0.6 |
| 14741996 | 3.2 ± 0.4 | 4.2 ± 0.1 | 3.9 ± 0.1 |
| 22406746 | 4.1 ± 0.2 | 2.3 ± 0.2 | 2 ± 0.1 |
| 14740150 | 4.4 ± 0.1 | 1.9 ± 0.1 | 3.0 ± 0.1 |
| 7976354 | 4.6 ± 0.1 | 0.9 ± 0.1 | 3.5 ± 0.1 |
a
values represent averages of two experiments ± range; highest concentration assessed 37.5 μM
b
values represent averages of four experiments ± SD; highest concentration assessed 37.5 μM