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Liver pharmacokinetics. The clearance of the agent from the liver is initially rapid. The activity per tissue volume of the agent decreased over 60% the first four hours after injection. Calculated corresponding concentration of the agent falls to 18μM after 4h, well below the EC50 found for macrophages in culture (EC50 > 450μM for 1h, EC50 = 40μM for 24h). Error bars reflect standard error.
