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. Author manuscript; available in PMC: 2008 Sep 29.
Published in final edited form as: Bioconjug Chem. 2006;17(2):538–547. doi: 10.1021/bc060018k

Table 1.

Relaxivities of prepared agents compared to other reported agents. Relaxivities increase with increasing Gd-DOTA incorporation, reaching an apparent plateau above 15 Gd/molecule.

Contrast Agent r1 per Gd (mM-1 s-1) Temp. and Field Strength Molecular Weight BSA-DOTA only (Da) Final Molecular Weight (Da) Gd ion per DOTA
Mal-BSA (Gd-DOTA)22 29.1 RT, 26MHz 79142 85898.7 19.8
Mal-BSA (Gd-DOTA)18 33.4 RT, 26MHz 76607.5 82317.2 11.9
Mal-BSA (Gd-DOTA)15 31.2 RT, 26MHz 74844.5 82455 14
Mal-BSA (Gd-DOTA)10 20.0 RT, 26MHz 71702.2 77490.6 6.7
Mal-BSA (Gd-DOTA)6 12.2 RT, 26MHz 69535.6 75954.1 4.4
Mal-BSA (Na-DOTA)6 0.09 RT, 26MHz 69535.6 — 0