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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Pain. 2008 Apr 3;9(7):639–649. doi: 10.1016/j.jpain.2008.02.002

Figure 3. The PPARγ antagonist, bisphenol A diglycidyl ether (BADGE), dose-dependently reverses the antiallodynic effect of 15d-PGJ2.

Figure 3

Panel A illustrates the time course of mechanical threshold following intrathecal co-injection of 15d-PGJ2 (100 μg) and BADGE, 7d after spared nerve injury (SNI). Panel B illustrates the change in mechanical threshold averaged from 30 to 90 min after injection (Mean Δ in Threshold), and indicates that thresholds in the 5, 25, and 100 μg BADGE+15d-PGJ2 groups were different from 15d-PGJ2 controls. Panel C illustrates the log dose-response curve at 60 min after injection. Vehicle for BADGE was DMSO. Values represent mean ± SEM, n=4-8. *P < 0.05.