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. Author manuscript; available in PMC: 2008 Sep 29.
Published in final edited form as: Biochemistry. 2005 Aug 30;44(34):11315–11322. doi: 10.1021/bi051061i

FIGURE 2.

FIGURE 2

Interactions of loop 2 nucleotides with stem 1 base pairs (carbon atoms colored in blue and yellow, respectively). Formation of the minor groove triplex is RNA-specific as 2’-hydroxyl groups are involved at every level. a, A20 interacts with two base pairs of stem 1 (G3:C16 and C4:G15), and multiple hydrogen bonds involving 2’-hydroxyl groups can be clearly seen. b, interactions between A21/C22 and C4:G15. c, Interaction between A23 and G5:C14. d, interaction between A24 and G6:C13. Note that loop 2 (blue) moves from one strand of stem 1 to the other between A21 and A24.