Table 1.
Brain regions | D3+/+ | D3+/− | D3−/− |
---|---|---|---|
Nucleus accumbens, core | 1.44 ± 0.26 | 1.74 ± 0.35 | 1.27 ±0.19 |
Nucleus accumbens, medial shell | 5.66 ± 0.62 | 6.39 ± 0.73 | 7.71 ± 0.60 |
Nucleus accumbens, lateral shell | 18.87 ±3.23 | 16.22 ±1.30 | 18.88 ±3.37 |
Olfactory tubercle | 13.47 ±1.90 | 10.00±1.16 | 12.08 ±1.32 |
Lateral septum | 19.63 ±1.62 | 22.49 ± 2.20 | 21.39 ±1.95 |
Dorsomedial striatum, rostral | 1.76 ± 0.30 | 2.11 ±0.34 | 1.87 ± 0.24 |
Dorsomedial striatum, caudal | 6.58 ± 2.61 | 6.73 ± 1.95 | 8.62 ± 2.76 |
Dorsolateral striatum, rostral | 1.75 ±0.16 | 1.86 ± 0.30 | 1.49 ±0.16 |
Dorsolateral striatum, caudal | 0.52 ±0.1 8 | 0.69 ±0.1 3 | 0.64 ±0.11 |
Ventrolateral striatum, rostral | 1.96 ± 0.42 | 1.79 ± 0.37 | 1.38 ± 0.22 |
Ventrolateral striatum, caudal | 1.36 ± 0.25 | 1.33 ± 0.20 | 1.09 ±0.16 |
In situ hybridization autoradiograms from vehicle-treated mice from the first experiment (shown in Figs. 2 and 3) were quantified with a computer-assisted image analysis system at rostral (bregma 0.98 mm) and caudal (bregma −0.10 mm) levels. Results are expressed as nCi/mg tissue (mean ± SEM); n = 4–7 mice per group. There were no significant differences in basal NT mRNA expression among D3−/−, D3+/− and wild-type mice in any of the regions studied.