Table 3.
Results of Simulated Diseases Studies in Two Uyghur Populations
| Uyghur Population | No. of Marker | Mapping Power (%) | No. of Cases Neededa | LD in Parental Populationb | False-Positive Resultsc | Control-Only LOD |
Case-Control LOD |
||
|---|---|---|---|---|---|---|---|---|---|
| Local | Global | Local | Global | ||||||
| Northern | 7,999 | 78 | 451 | ++ | − | 0.3 | −2.9 | 10.8 | 7.6 |
| Northern | 4,039 | 69 | 509 | + | − | −1.3 | −3.3 | 5.4 | 2.4 |
| Northern | 2,714 | 61 | 576 | − | − | −0.1 | −2.4 | 7.3 | 4.6 |
| Northern | 1,396 | 45 | 781 | − | − | 0.1 | −2.2 | 5.2 | 2.6 |
| Northern | 1,255 | 54 | 651 | − | − | 0.4 | −1.8 | 11.9 | 9.3 |
| Southern | 2,750 | 54 | 577 | + | − | 0.7 | −1.4 | 7.8 | 4.9 |
| Southern | 1,804 | 43 | 724 | − | − | −0.8 | −3.1 | 8.3 | 5.5 |
| Southern | 1,021 | 46 | 677 | − | − | 0.4 | −1.5 | 13.2 | 10.3 |
a
Assumed increased disease risk of 1.5 with EAS ancestry at the disease locus.
b
LD presents in EAS and EUR for a few adjacent marker pairs, ++ denotes strong LD (r2 >0.5), + denotes moderate LD (r2 >0.2), and - denotes weak or no LD (r2 <0.2).
c
False-positive results are indicated by genome-wide LOD score in control-only study, + denotes false-positive results (global LOD >0) present, and - denotes no false-positive results (global LOD <0).. Local and global LOD scores were averaged across ten control-only simulations and ten case-control simulations.