TABLE 3.
Arg AVAILABILITY BY PRESENCE OF ASTHMA AND ASTHMA CATEGORY
| Asthma Status
|
Among All Groups P Value* | Severe vs. Nonsevere Asthma
|
||||
|---|---|---|---|---|---|---|
| Metabolic Parameter | Healthy (Control) | Nonsevere Asthma | Severe Asthma | P Value† | P Value‡ | |
| Arg, mM | 37.9 (3.35) | 41.1 (2.40) | 41.1 (2.40) | 0.618 | 0.17 | 0.79 |
| Orn, mM | 23.1 (1.9) | 19.1 (1.2) | 20.0 (1.2) | 0.167 | 0.23 | 0.96 |
| Cit, mM | 25.4 (3.1) | 22.0 (1.1) | 26.6 (1.9) | 0.088 | 0.034 | 0.17 |
| MMA, mM | 0.044 (0.002) | 0.040 (0.002) | 0.052 (0.004) | 0.012 | 0.006 | 0.037 |
| ADMA, mM | 0.331 (0.028) | 0.290 (0.011) | 0.346 (0.021) | 0.038 | 0.067 | 0.05 |
| SDMA, mM | 0.219 (0.013) | 0.190 (0.006) | 0.229 (0.013) | 0.012 | 0.021 | 0.025 |
| Arg/(Orn + Cit) | 0.843 (0.069) | 1.048 (0.052) | 0.997 (0.058) | 0.104 | 0.43 | 0.9 |
| Arg/(MMA + ADMA) | 105.2 (8.4) | 124.2 (4.9) | 116.0 (6.0) | 0.178 | 0.23 | 0.7 |
| Arg/(MMA + ADMA + SDMA) | 64.5 (4.7) | 78.0 (3.2) | 72.3 (3.5) | 0.101 | 0.17 | 0.6 |
Definition of abbreviations: ADMA = asymmetric dimethyl arginine; Arg = arginine; Cit = citrulline; MMA = monomethylarginine; Orn = ornithine; SDMA = symmetric dimethyl arginine.
Data in left columns are presented as mean (SE). Values in bold indicate R values of spearman correlations with significant P < 0.05.
P value from linear modeling, controlling for age, sex, systemic corticosteroid use; systemic corticosteroid use is defined as “yes” to receives oral or intravenous corticosteroids at least monthly.
P value for severe vs. nonsevere based on Wilcoxon rank sum test.
P value from linear modeling with Tukey adjustment for multiple pairwise comparisons between control subjects, individuals with nonsevere asthma, and those with severe asthma.