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Histologic samples of distal lung parenchyma of 90-day-old old mice. A and C represent the alveolar parenchyma of nonexposed mice, with a normal histologic aspect. In the 90-day-old pre+postanally exposed mice sparse, mild foci of macrophages could be observed (B and D). In some macrophages of these animals, minute, black dots of carbon pigment could be observed (D, inset). a = alveolar spaces, mo = macrophages. Scale bar: A, B = 100 μm; C, D = 25 μm.
