Figure 5.

A measure of the percent short telomeres [logit(p)] for (A) normal control subjects, (B) probands of kindreds with familial pulmonary fibrosis, and (C) sporadic cases with idiopathic interstitial lung disease plotted against age. Open circles represent normal control subjects, red triangles represent unrelated probands and sporadic cases with pulmonary fibrosis, solid circles represent probands and sporadic cases with pulmonary fibrosis and TERT or TERC mutations. The blue region delineates the 10th to 90th percentile predicted bands of the logit(p) for the normal control subjects. Linear regression analysis of the logit(p) established a linear relationship for normal subjects between this measure and age by the following equation (where p is the percentage of short telomeres): logit(p) = ln[p/(1 – p)] = −2.56 + 0.0148 × age (P = 3.4 × 10⁻¹²).