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Stability in Caco-2 homogenate - First order degradation rate constants and half lives of all prodrugs.
| Drug | K*103 (hr−1) | T1/2 (hr) |
|---|---|---|
| LLACV | 92.23 ± 4.79 | 7.52 ±0.40 |
| LDACV | 13.33 ±1.96 | 52.80 ±8.42 |
| DLACV | * | * |
| DDACV | * | * |
| D-Val-ACV | 29.86 ± 4.71 | 23.56 ± 3.42 |
- no degradation during the time of study. Each value is represented as mean ± stdev. (n=3)
