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Stability in rat intestinal homogenate - First order degradation rate constants and half lives of all prodrugs.
| Drug | K*103 (hr−1) | T1/2 (hr) |
|---|---|---|
| LLACV | - | < 0.08 |
| LDACV | 688.23 ± 48.68 | 1.01 ± 0.07 |
| DLACV | 110.06 ± 4.52 | 6.27 ± 0.25 |
| DDACV | * | * |
represents no degradation during the time of study. (-) represents the whole prodrug degraded in less than first sampling time point (5min). Each value is represented as mean ± stdev. (n=3)
