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Stability in rat liver homogenate - First order degradation rate constants and half lives of all prodrugs.
| Drug | K*103 (hr−1) | T1/2 (hr) |
|---|---|---|
| LLACV | - | < 0.08 |
| LDACV | 1388.23 ± 64.24 | 0.49± 0.02 |
| DLACV | 245.06 ± 11.25 | 2.82 ± 0.18 |
| DDACV | * | * |
represents no degradation during the time of study. (-) represents the whole prodrug degraded in less than first sampling time point (5min). Each value is represented as mean ± stdev. (n=3)
