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. Author manuscript; available in PMC: 2009 May 16.
Published in final edited form as: J Mol Biol. 2008 Mar 26;378(5):1052–1063. doi: 10.1016/j.jmb.2008.03.033

Figure 3. R domain size is increased by phosphorylation-mimicking S→E substitutions.

Figure 3

Radius of gyration of the WT and S→E R domain are collected from trajectories of equilibrium simulations. Histograms had been generated and Gaussian fitting is performed to determine the peaks of the WT (18.2 Å, 19.1 Å) and the S→E (19.7 Å, 22.1 Å) distributions. Kolmogorov-Smirnov test is used to verify the difference between the two distributions (P-value = 0.03). A more closed conformation of the WT domain is depicted on the left (green), and a more open conformation of the S→E R domain on the right (red).