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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Neurobiol Learn Mem. 2008 Jun 23;90(2):443–454. doi: 10.1016/j.nlm.2008.05.010

Figure 4.

Figure 4

Effects of paired tone–NBstm training on behavioral memory without and with the block of cholinergic transmission immediately following training. (A) Examples of respiratory waveforms obtained from a Saline subject. Shown are baseline responses to the CS (8.00 kHz) and a lower (2.75 kHz) and higher (15.00 kHz) frequency during Day 2 (“Before”) and Day 4, 24 h post-training (“After”). RCI values indicate the quantified effect of tone on respiration. Before training, responses to all three frequencies were minimal. However, after training, the CS frequency produced a large disruption of respiration (RCI = 0.46). The specificity of this index of NB-induced behavioral memory is indicated by the absence of responses to the lower and higher frequencies. (B) Examples of respiratory waveforms from a subject in the Scopolamine group. Similar to the Saline group, responses before training were minimal. In contrast to the Saline group, there was also a minimal response to the CS frequency (as well as the lower and higher frequencies) after training (CS RCI = 0.09). Note that both subjects had the same level of NBstm (72 μA) during pairing. The thick horizontal bars indicate tone presentation.